Our movements are partly ordened by a
biochemical substance, the dopamine,
secreted by specialized cells from a center
located in brain's base (black substance,
also said locus niger).
When those cells which secretes
dopamine die or are damaged, one sees
appearing the symptoms of Parkinson's
disease.
|
Parkinson's
disease symptoms |
| Mobility
symptoms |
Non mobility symptoms |
shakings
muscular rigidity
slowness of movements
balance troublesshakings
|
constipation
disturbed sleep
urgencies
to urinate
|
fatigue
depression
memory
disorders
dizzynesses
|
|
Parkinson's
disease treatment |
|
It exists no curative
treatment against Parkinson's
disease |
|
Dopamine
treatment
|
Inhibitors mono amine oxydase
*
|
Exceptional
treatments
|
Agonists of dopamine
Dopamine (L.Dopa) |
|
Surgical treatment (Deep
cerebral stimulation)
Stem cells. (Research)
|
*An inhibitor of mono amine oxydase (IMAO)
is a molecule which blocks the degrading
dopamine enzyme.
An old
publication going back to 1974 deserves our
attention. It is about a clinical study
evaluating the action of testosterone on
activity of mono amino oxydase in depressed
patients.
Conclusion of
this ststudy : Testosterone given in
apropriate amounts
lowers naturally
the MAO
(Mono amino
oxydase) preventing the degradation of
dopamine (1)
|
Mean
MAO
activity
(monoamine oxydase)
in
plasma
|
|
Before treatment
|
7223 ± 3740
|
|
After
treatment
|
1997 ± 1250 (p<0,01)
|
|
400 mgrs.
testosterone
cipìonate
every
21
days
|
Effect of a
treatment with testosterone on the activity
of the plasmatic MAO in 7 depressed men
(according to Klaiber and coll) (1)
From there the
interest to study the
daily
androgens' production among patients
presenting a Parkinson's disease with the
aim of substituting their missing androgens
in order to
save their production of dopamine.
1. KLAIBER E.L., BROVERMAN
D.M., VOGEL W., KOBAYASHI Y. The use of
steroid hormones in depression. in
Psychotropic action of hormones. Proceedings
of the World Cogress of biological
psychiatry. Buenos Aires. Argentina,
september 1974. Spectrum publications INC.
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