TEStosterone
secretion decreases regularly from the age of 20 in woman:
The expected Testosterone concentration
in the blood of a woman of 40 would be about half that of a
woman of 21 (2).
ORAL CONTRACEPTIVE TROUBLES
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Birth Control Guide of FDA
Women using OCs (OC=Oral contraceptive) had significantly
lower serum androgen levels compared to naturally cycling
women and free
testosterone levels displayed an inverse relation to
breast
epithelial proliferation
(3.1).
OC
use, however, has been associated with women's sexual health
complaints and
androgen
insufficiency.
OC use is
associated with a decrease of
androgen
ovarian synthesis and an increase in the production of sex
hormone-binding globulin (SHBG) even months after the stop
of OC. Troubles may
persist after stopping the OC(4).
CONSEQUENCES OF ORAL CONTRACEPTIVE TROUBLES WITH
Decrease of
androgen ovarian synthesis
|
Thrombosis of the Deep Veins (3)
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Hypertension (14/9) after 5 years of continuous use
( 5% of the cases) (3)
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Pulmonary embolism (risks
x 2 to 12) .(3)
|
Disturbances of the plasmatic lipoproteins.(3)
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Cerebral thromboembolism (risks x 3 to 9)
(3)
|
Resistance to insulin.(3)
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Cerebral hemorrhage (risks x 2) (3)
|
|
Breast cancer risk
|
(3.1) (3.2) (3.3)
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Sexual health complaints
|
(4)
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BILATERAL OOPHORECTOMY
PREMENOPAUSE
In this condition balance between estradiol and progesterone
could be impaired leading to fibromyoma of the uterus,
spotting and bleeding. Androgen’s deficiency will be also
considered in those cases.
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