ALZHEIMER'S DISEASE
Understanding
diseases of aging:
ageless woman
Recent and decisive scientific discoveries
1999-2000 (1)
The nerve cells in culture treated with testosterone
secrete less amyloidogenic peptides.
Conclusion of this study: Androgens could be
protection against the development of Alzheimer's
disease (1).
2001 (2)
The first clinical description of the
increase in the level of β-amyloid protein in the
blood was published in 2001 by a team of researchers
from the University of Western Australia in Perth
(2). They demonstrated that:
Chemical castration causes the collapse of
testosterone and plasma estradiol in humans in
parallel with the elevation of amyloid beta protein
Chemical Andropause and Amyloid-
Peptide
(JAMA. 2001;285:2195-2196)
Figure. Plasma Concentrations of Amyloid- Peptide (A), Testosterone, and 17-Estradiol From 6 Men With Adenocarcinoma of the Prostate.
Plasma concentrations were determined serially on samples drawn 1 week prior to
initiating treatment with flutamide and leuprorelin acetate and on weeks 4, 12,
and 24.
Conclusion
de cette étude : le remplacement hormonal peut
prévenir ou retarder la maladie d'Alzheimer chez
l'homme andropausé
2004 (3)
In 2004 researchers at the University of
Southern California "studied the testosterone
content of the brain in deceased men. Two groups
were studied:
The first group had no neuropathological
abnormality (control group),
The second group had either Alzheimer's disease
or moderate neuropathological disorders.
Conclusion of this study: the brain
tissue of patients with Alzheimer's disease
contains significantly less testosterone than
the brain tissue of men with no
neurophysiological abnormality (3)
2006 (4)
A clinical study was conducted for two years
by researchers at the Department of Neurology,
David Geffen School of Medicine, University of
California, Los Angeles, USA., by a double-blind
study of 16 men with Alzheimer's disease
compared to 22 men without neurological
problems, all treated with testosterone.
Conclusion of this study: the
quality of life of men with Alzheimer's disease
treated with testosterone was improved in
general. Testosterone had a minimal effect on
cognition (4).
2008 (5)
Emily R. Rosario and Christian J. Pike of the
Davis School of Gerontology, University of
Southern California, Los Angeles, CA 90089 USA
publish a review of scientific publications
devoted to Alzheimer's disease.
Download pdf. (5)
Conclusion of this review:
-
Alzheimer's disease demonstrates an
abnormal accumulation of amyloid β-protein in
the brain.
-
Recent data suggest the regulatory action
of androgens on amyloid β protein and on the
development of Alzheimer's disease.
-
Androgen therapy can be considered to
prevent and treat Alzheimer's disease
2011 (6)
An article in the American Academy of Family
Physicians highlights the contradictions in the
treatment of Alzheimer's disease with testosterone
(6)
***
Hopes uncovered - news as of November 23,
2016
What are
the pathological lesions of the brain in
Alzheimer's disease?
What can
be the mechanism of this degeneration ?
Testosterone production decreases with age
in men and women
The androgen
production chain in women
Recent
and decisive scientific discoveries
Hopes that will
not be disappointed to prevent Alzheimer's
disease
Understanding
diseases of aging:
ageless woman
Bibliography
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